What is Mesothelioma?
Mesothelioma is a rare and aggressive cancer that forms on the protective lining covering the lungs, abdomen, testicles, or heart. Mesothelioma is caused by exposure to asbestos Contrary to some belief, mesothelioma is not hereditary and its only known cause is exposure to asbestos fibers.
This fatal disease can lay dormant for years or decades before developing. While there is no cure for mesothelioma, treatment options are available to reduce symptoms and help improve quality of life while living with the disease. Many symptoms of mesothelioma can also appear as the result of other, less serious diseases or illnesses, and are commonly mistaken for more minor ailments. Often, mesothelioma symptoms persist for months before a patient is properly diagnosed.
Being aware of the symptoms, particularly if you have a known exposure to asbestos, can improve the chances of obtaining the earliest possible diagnosis. Early diagnosis can result in more effective mesothelioma treatment options.
Symptoms and signs of mesothelioma:
- Coughing
- Fatigue
- Pain in lower back or side of the chest
- Respiratory infection
- Shortness of breath or painful breathing
- Sudden and unexplained weight loss
- Bowel and digestive difficulties
- Fever
- Swelling and fluid buildup
While there is no cure for mesothelioma, prompt and effective treatment can help alleviate painful symptoms and slow down cancer’s pace to provide patients with longer and better lives.
Types of Mesothelioma
There are four different types of mesothelioma, diagnosed by the starting location of the cancer. What each type has in common, though, is that they are all linked to asbestos exposure. When dangerous, microscopic asbestos fibers find their way into our bodies, they embed themselves into the soft tissue linings of organs. Unfortunately, our bodies have no way to break down these microscopic fibers, so they remain, causing continual damage at the cellular level.
This causes the damaged DNA formerly responsible for creating new, healthy cells to create cancerous cells instead. Knowing the basics of each mesothelioma type can aid in earlier diagnosis, which, in turn, can help to extend the life of the individual through proper treatment.
Pleural Mesothelioma
The most common type of mesothelioma is pleural mesothelioma, which is caused by inhaling airborne asbestos fibers. This accounts for nearly 90% of all mesothelioma diagnoses. Pleural mesothelioma is cancer that afflicts the pleura, or the lining of our lungs, which is responsible for reducing internal friction while the lungs expand and deflate as they work. Damage caused by this cancer results in scarring that thickens the pleura, making breathing difficult and increasing the chances of fluid buildup in the lungs.
Unfortunately, the early signs of pleural mesothelioma can be very mild, often resulting in a lack of diagnosis or a misdiagnosis. Early signs and symptoms can include:
- Chest pain or painful breathing
- Fatigue
- Shortness of breath
- Persistent coughing
- Difficulty breathing
- Night sweats
As pleural mesothelioma progresses, additional signs and symptoms can include:
- Nausea
- Fevers
- Faintness
- Difficulty swallowing
- Coughing up blood
- Pain in the chest, ribs, or lower back
- Peritoneal Mesothelioma
Peritoneal mesothelioma is the second most common type of mesothelioma and afflicts the peritoneum, or the abdominal cavity lining. The peritoneum is a thin, protective tissue that lines several major organs, including both intestines and the stomach. Peritoneal mesothelioma is most often caused by ingested asbestos fibers, whether by swallowing airborne particles or drinking contaminated water. The asbestos fibers are durable enough to survive digestion, which leads to them becoming trapped in the lining.
Symptoms for peritoneal mesothelioma can include:
- Abdominal pain
- Abdominal swelling
- Fatigue
- Unexplained weight loss
- Diarrhea
- Constipation
- Loss of appetite
- Night sweats
- Pericardial Mesothelioma
Mesothelioma that develops in the lining of the heart, or pericardium, is known as pericardial mesothelioma. This is the second rarest form of mesothelioma, accounting for less than 1% of all diagnoses. The exact cause of pericardial mesothelioma remains a mystery even today. Due to pericardial mesothelioma affecting the heart, symptoms can be very severe, even in the earliest stages. It is also often misdiagnosed for other conditions such as heart failure, coronary heart disease, cardiomyopathy, and more.
Symptoms for pericardial mesothelioma can include:
- Chest pain
- Fatigue
- Fever
- Persistent coughing
- Difficulty breathing
- Shortness of breath
- Night sweats
- Heart palpitations
- Irregular heartbeat
- Testicular Mesothelioma
Testicular mesothelioma develops in the lining of the testicles, or tunica vaginalis, and is the rarest form of mesothelioma to be diagnosed. Causes for testicular mesothelioma are not easily traced. To date, the exact cause of this cancer has not been singled out. In later stages, tumors can develop on the surface of the testicles, appearing as firm, whitish nodules. Testicular mesothelioma is considered very aggressive, tending to spread rapidly and recur even after surgical removal of the tumors.
Symptoms for testicular mesothelioma can include:
- Mass on the testicles
- Testicular pain
- Thickening of the tunica vaginalis
- Swelling of the testicles
- Fluid buildup
- Fever
- Night sweats
Diagnosing Mesothelioma
Diagnosing mesothelioma requires multiple tests that help confirm its existence and to track its spread. If the cancer has spread (called metastasis), imaging tests will reveal this and help your doctor decide if more tests are needed and which treatments could work for you.
Mesothelioma can be confused with lung cancer, as it's a challenge to diagnose and has similarities. One of the biggest indicators of mesothelioma is when fluid builds up in the space around the lungs (pleural effusion) or in the abdomen (ascites). The fluid can be tested for cancer cells and is usually the first step to diagnosing mesothelioma. A biopsy will then be needed to confirm it's mesothelioma.
A biopsy is the only way a doctor can confirm most cancers. This happens after imaging has taken place and involves your doctor taking a small sample of the tissue in question and sending it to a lab for testing. If doing a biopsy isn't an option, there are others that can help provide a diagnosis that your doctor will recommend.
Mesothelioma Diagnosis Options
To develop a treatment plan specific to you and your stage of cancer, your doctor will conduct or order:
A physical exam and evaluation of your health history
- Blood tests
- X-rays
- Lung function tests
- A CT scan
- An MRI
- A PET-CT scan
All of these will help the doctor explain your diagnosis and staging.
Mesothelioma Treatment Options
When you receive a cancer diagnosis, you won't only be dealing with one doctor. There is a multidisciplinary cancer care team that works to create your overall treatment plan, including physician assistants, oncology nurses, pharmacists, dieticians, counselors, and so on. An important part of mesothelioma care is not just keeping the cancer under control, but making sure that all symptoms and side effects are minimized
.Mesothelioma does not have a cure, per se, but there are many treatments that can be done to help minimize its effects on your life. It's important to discuss all of your treatment options with your doctor so that you can decide together which will fit your needs.
Surgery
Surgery can be a treatment option for mesothelioma patients. This includes the removal of cancerous tissue, which may sometimes include the removal of lining of the lung, the entire lung, the lining of abdominal organs, a portion of the diaphragm or a portion of the lining around the heart. This is a difficult surgery and the doctor will usually decide if this is a good option and will typically recommend chemotherapy or radiation therapy before or after surgery.
Medication Therapies
The use of medication to destroy cancer cells is called systemic therapy. It is given through the bloodstream via intravenous (IV) tubes or in pill form (swallowed orally) to ensure it reaches all cancer cells throughout the body. Types of systemic therapy that can be used in mesothelioma treatment include chemotherapy, immunotherapy, and targeted therapy. They can be used one at a time or in combination with each other. They can also be used in a treatment plan that includes surgery and/or radiation therapy.
Radiation Therapy
The use of high-energy x-rays or other particles to destroy cancer cells is called radiation therapy. The most common type is called external-beam radiation and radiation are given using a machine outside the body. Typically, radiation therapy has a schedule of a specific number of treatments over a period of time. This therapy is not as common with mesothelioma patients because it has been known to cause some uncomfortable or severe side effects.
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